PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
نویسندگان
چکیده
Department of Biopharmaceutical Sciences (T.D.N., J.M.G., L.W.C., L.K., A.S., K.M.G., D.L.K.), Program in Human Genetics (K.M.G., D.L.K.), and Department of Pharmaceutical Chemistry (C.C.H., D.S., M.K., S.J.J., T.E.F.) and Genomics Core Facility, Program in Human Genetics (E.J.C., T.T.), University of California, San Francisco, San Francisco, California; and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California (H.J.)
منابع مشابه
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
Departments of Biopharmaceutical Sciences (I.B., M.S., R.A.C., C.B., E.G.B., D.L.K., K.M.G.), Pharmaceutical Chemistry (C.C.H., D.S., M.K., S.J.J., T.E.F.), and Biochemistry and Biophysics (I.H.), University of California, San Francisco, San Francisco, California; Department of Neurology and Physiology, School of Medicine, University of California, San Francisco, San Francisco, California (R.H....
متن کاملAutomating Data Acquisition into Ontologies from Pharmacogenetics Relational Data Sources Using Declarative Object Definitions and XML
Ontologies are useful for organizing large numbers of concepts having complex relationships, such as the breadth of genetic and clinical knowledge in pharmacogenomics. But because ontologies change and knowledge evolves, it is time consuming to maintain stable mappings to external data sources that are in relational format. We propose a method for interfacing ontology models with data acquisiti...
متن کاملPharmGKB: A Resource to Link Genotype and Phenotype in Pharmacogenetics
The PharmGKB (http://www.pharmgkb.org/) is a pharmacogenetics and pharmacogenomics knowledge base built to support the representation, storage, analysis and dissemination of genotype and phenotype data. We have collected genetic sequence data from research centers in which polymorphic variations in genes of pharmacogenetic interest have been characterized in particular populations. PharmGKB als...
متن کاملThe role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance
Acute lymphoblastic leukemia (ALL) is one of the most prevalent hematologic malignancies in children. Although the cure rate of ALL has improved over the past decades, the most important reason for ALL treatment failure is multidrug resistance (MDR) phenomenon. The current study aims to explain the mechanisms involved in multidrug resistance of childhood ALL, and introduces ATP-binding cassette...
متن کاملA SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions
MOTIVATION Genetic factors determine differences in pharmacokinetics, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reactions in individuals whose drug metabolism drastically differs from the "assumed average". Databases such as PharmGKB are excellent sources of pharmacogenetic information on enzymes, genetic va...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Pharmacological reviews
دوره 58 1 شماره
صفحات -
تاریخ انتشار 2006